I clean my room by starting with the bed. Once my bed is made, I start cleaning up any dirty clothes that may have been left in the floor. From there, I start picking up the things that do not belong in my bedroom such as kids toys, trash, etc. Then I start putting things where they go until it is clean.
I vacuum my room once a week and everyday when I return back home I organize things to their usual places. Then I may do laundry or empty the dishwasher.